ELASPIC home << Job #oncokb << Q9Y6K1.R882H
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q9Y6K1.R882H

Detailed results for job #oncokb produced by ELASPIC
Q9Y6K1, DNA (cytosine-5)-methyltransferase 3A:
R882H
1
912
PWWP
DNA_methylase
DNMT3B, DNA (cytosine-5)-methyltransferase 3B:
1
853
PWWP
DNA_methylase
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Model: Wild-type | Mutant | Both
Protein: Q9Y6K1 | DNMT3B | Cofactors | All
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Q9Y6K1.R882H

Completed successfully

Protein, domain: Q9Y6K1 DNA_methylase

Interacting with: DNMT3B DNA_methylase

PDB templates used: 2qrv_A, 2qrv_D

Seq identity: 0.950, 0.763 Model score: -0.499

ELASPIC ΔΔG: 1.155

ELASPIC2 (EL2) score: -0.158

Mutation in databases: UniProt, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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