ELASPIC home << Job #oncokb << Q9UM73.T1343I
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q9UM73.T1343I

Detailed results for job #oncokb produced by ELASPIC
Q9UM73, ALK tyrosine kinase receptor:
T1343I
1
1620
Pkinase_Tyr
MYLK isoform 5, Isoform 4 of Myosin light chain kinase, smooth muscle:
1
1841
I-set+I-set+I-set+I..
Pkinase
I-..
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Q9UM73.T1343I

Completed successfully

Protein, domain: Q9UM73 Pkinase_Tyr

Interacting with: MYLK isoform 5 Pkinase

PDB templates used: 2xzs_A, 2xzs_B

Seq identity: 0.263, 0.507 Model score: 0.172

ELASPIC ΔΔG: 1.205

ELASPIC2 (EL2) score: -1.280

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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