ELASPIC home << Job #oncokb << Q9UM73.S1206Y
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q9UM73.S1206Y

Detailed results for job #oncokb produced by ELASPIC
Q9UM73, ALK tyrosine kinase receptor:
S1206Y
1
1620
Pkinase_Tyr
M3K4 isoform 2, Isoform 2 of Mitogen-activated protein kinase kinase kinase 4:
1
1558
Pkinase
Select affected interaction:

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Q9UM73.S1206Y

Completed successfully

Protein, domain: Q9UM73 Pkinase_Tyr

Interacting with: M3K4 isoform 2 Pkinase

PDB templates used: 3lvp_C, 3lvp_B

Seq identity: 0.461, 0.237 Model score: 0.374

ELASPIC ΔΔG: 0.614

ELASPIC2 (EL2) score: 1.028

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.