ELASPIC home << Job #oncokb << Q9UM73.P1139S
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q9UM73.P1139S

Detailed results for job #oncokb produced by ELASPIC
Q9UM73, ALK tyrosine kinase receptor:
P1139S
1
1620
Pkinase_Tyr
ACK1 isoform 2, Isoform 2 of Activated CDC42 kinase 1:
1
528
Pkinase_Tyr
GTPa..
SH3_9
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Q9UM73.P1139S

Completed successfully

Protein, domain: Q9UM73 Pkinase_Tyr

Interacting with: ACK1 isoform 2 Pkinase_Tyr

PDB templates used: 4ewh_A, 4ewh_B

Seq identity: 0.346, 0.996 Model score: -0.421

ELASPIC ΔΔG: 0.905

ELASPIC2 (EL2) score: -0.824

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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