ELASPIC home << Job #oncokb << Q9UM73.G1286R
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q9UM73.G1286R

Detailed results for job #oncokb produced by ELASPIC
Q9UM73, ALK tyrosine kinase receptor:
G1286R
1
1620
Pkinase_Tyr
MAP3K3, Mitogen-activated protein kinase kinase kinase 3:
1
626
PB1
Pkinase
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Protein: Q9UM73 | MAP3K3 | Cofactors | All
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Q9UM73.G1286R

Completed successfully

Protein, domain: Q9UM73 Pkinase_Tyr

Interacting with: MAP3K3 Pkinase

PDB templates used: 4ibm_A, 4ibm_B

Seq identity: 0.457, 0.243 Model score: 0.086

ELASPIC ΔΔG: 0.823

ELASPIC2 (EL2) score: 1.863

Mutation run by user.

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Citation

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