ELASPIC home << Job #oncokb << Q92963.F82L
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q92963.F82L

Detailed results for job #oncokb produced by ELASPIC
Q92963, GTP-binding protein Rit1:
F82L
1
219
Ras
NF2, Merlin:
1
595
ERM
FERM_N+FERM_M+FERM_C
Select affected interaction:
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Protein: Q92963 | NF2 | Cofactors | All
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

Q92963.F82L

Completed successfully

Protein, domain: Q92963 Ras

Interacting with: NF2 FERM_N+FERM_M+FERM_C

PDB templates used: 4dxa_A, 4dxa_B

Seq identity: 0.500, 0.226 Model score: 0.144

ELASPIC ΔΔG: -0.019

ELASPIC2 (EL2) score: 1.648

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.