ELASPIC home << Job #oncokb << Q15796.Y406H
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q15796.Y406H

Detailed results for job #oncokb produced by ELASPIC
Q15796, Mothers against decapentaplegic homolog 2:
Y406H
1
467
MH1
MH2
SMAD6 isoform 2, Isoform B of Mothers against decapentaplegic homolog 6:
1
235
MH2
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Q15796.Y406H

Completed successfully

Protein, domain: Q15796 MH2

Interacting with: SMAD6 isoform 2 MH2

PDB templates used: 1u7v_A, 1u7v_B

Seq identity: 1.000, 0.366 Model score: -0.623

ELASPIC ΔΔG: 2.391

ELASPIC2 (EL2) score: 1.554

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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