ELASPIC home << Job #oncokb << Q15796.R321Q
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q15796.R321Q

Detailed results for job #oncokb produced by ELASPIC
Q15796, Mothers against decapentaplegic homolog 2:
R321Q
1
467
MH1
MH2
SMAD7 isoform 3, Isoform 3 of Mothers against decapentaplegic homolog 7:
1
425
MH1
MH2
Select affected interaction:
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

Q15796.R321Q

Completed successfully

Protein, domain: Q15796 MH2

Interacting with: SMAD7 isoform 3 MH2

PDB templates used: 1u7v_A, 1u7v_C

Seq identity: 1.000, 0.347 Model score: -0.615

ELASPIC ΔΔG: 0.949

ELASPIC2 (EL2) score: 1.755

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.