ELASPIC home << Job #oncokb << Q15796.D450E
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q15796.D450E

Detailed results for job #oncokb produced by ELASPIC
Q15796, Mothers against decapentaplegic homolog 2:
D450E
1
467
MH1
MH2
SMAD5, Mothers against decapentaplegic homolog 5:
1
465
MH1
MH2
Select affected interaction:

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Model: Wild-type | Mutant | Both
Protein: Q15796 | SMAD5 | Cofactors | All
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Q15796.D450E

Completed successfully

Protein, domain: Q15796 MH2

Interacting with: SMAD5 MH2

PDB templates used: 1u7v_C, 1u7v_A

Seq identity: 1.000, 0.806 Model score: -0.945

ELASPIC ΔΔG: 1.172

ELASPIC2 (EL2) score: 1.373

Mutation in database: UniProt.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.