ELASPIC home << Job #oncokb << Q15303.T926M
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q15303.T926M

Detailed results for job #oncokb produced by ELASPIC
Q15303, Receptor tyrosine-protein kinase erbB-4:
T926M
1
1308
Pkinase_Tyr
Furin..
Recep_L..
Recep_L_..
GF_rec..
P55G isoform 2, Isoform 2 of Phosphatidylinositol 3-kinase regulatory subunit gamma:
1
402
SH2+SH2
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Q15303.T926M

Completed successfully

Protein, domain: Q15303 Pkinase_Tyr

Interacting with: P55G isoform 2 SH2+SH2

PDB templates used: 4gl9_A, 4gl9_E

Seq identity: 0.358, 0.312 Model score: 0.231

ELASPIC ΔΔG: 0.162

ELASPIC2 (EL2) score: -0.063

Mutation run by user.

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Citation

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