ELASPIC home << Job #oncokb << Q15303.S303Y
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q15303.S303Y

Detailed results for job #oncokb produced by ELASPIC
Q15303, Receptor tyrosine-protein kinase erbB-4:
S303Y
1
1308
Pkinase_Tyr
Furin..
Recep_L..
Recep_L_..
GF_rec..
ERBB4 isoform 2, Isoform JM-B CYT-1 of Receptor tyrosine-protein kinase erbB-4:
1
1298
Pkinase_Tyr
Furin..
Recep_L..
Recep_L_..
GF_rec..
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Q15303.S303Y

Completed successfully

Protein, domain: Q15303 Furin-like

Interacting with: ERBB4 isoform 2 Furin-like

PDB templates used: 1ivo_B, 1ivo_A

Seq identity: 0.478, 0.478 Model score: 1.667

ELASPIC ΔΔG: 1.487

ELASPIC2 (EL2) score: 1.007

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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