ELASPIC home << Job #oncokb << Q14145.R415G
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q14145.R415G

Detailed results for job #oncokb produced by ELASPIC
Q14145, Kelch-like ECH-associated protein 1:
R415G
1
624
BTB+BACK
Kelch_1
KEAP1, Kelch-like ECH-associated protein 1:
1
624
BTB+BACK
Kelch_1
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Protein: Q14145 | KEAP1 | Cofactors | All
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Q14145.R415G

Completed successfully

Protein, domain: Q14145 Kelch_1

Interacting with: KEAP1 Kelch_1

PDB templates used: 4l7b_A, 4l7b_B

Seq identity: 0.997, 0.997 Model score: -1.023

ELASPIC ΔΔG: 2.928

ELASPIC2 (EL2) score: -1.004

Mutation run by user.

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Citation

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