ELASPIC home << Job #oncokb << Q13485.R515A
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q13485.R515A

Detailed results for job #oncokb produced by ELASPIC
Q13485, Mothers against decapentaplegic homolog 4:
R515A
1
552
MH1
MH2
B7Z5N5, Mothers against decapentaplegic homolog 2:
1
431
MH1
MH2
Select affected interaction:

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Model: Wild-type | Mutant | Both
Protein: Q13485 | B7Z5N5 | Cofactors | All
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Q13485.R515A

Completed successfully

Protein, domain: Q13485 MH2

Interacting with: B7Z5N5 MH2

PDB templates used: 1u7v_B, 1u7v_A

Seq identity: 0.881, 0.988 Model score: -0.291

ELASPIC ΔΔG: 0.250

ELASPIC2 (EL2) score: 1.854

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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