ELASPIC home << Job #oncokb << Q13485.R496H
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q13485.R496H

Detailed results for job #oncokb produced by ELASPIC
Q13485, Mothers against decapentaplegic homolog 4:
R496H
1
552
MH1
MH2
SMAD4, Mothers against decapentaplegic homolog 4:
1
552
MH1
MH2
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Model: Wild-type | Mutant | Both
Protein: Q13485 | SMAD4 | Cofactors | All
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Q13485.R496H

Completed successfully

Protein, domain: Q13485 MH2

Interacting with: SMAD4 MH2

PDB templates used: 1dd1_C, 1dd1_B

Seq identity: 0.899, 0.929 Model score: -0.135

ELASPIC ΔΔG: 1.729

ELASPIC2 (EL2) score: 1.090

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.