ELASPIC home << Job #oncokb << Q13485.R420H
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q13485.R420H

Detailed results for job #oncokb produced by ELASPIC
Q13485, Mothers against decapentaplegic homolog 4:
R420H
1
552
MH1
MH2
SKIL, Ski-like protein:
1
684
c-SKI_SMA..
Ski_Sno
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Model: Wild-type | Mutant | Both
Protein: Q13485 | SKIL | Cofactors | All
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Q13485.R420H

Completed successfully

Protein, domain: Q13485 MH2

Interacting with: SKIL c-SKI_SMAD_bind

PDB templates used: 1mr1_B, 1mr1_C

Seq identity: 0.832, 0.495 Model score: 0.672

ELASPIC ΔΔG: 0.948

ELASPIC2 (EL2) score: 0.826

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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