ELASPIC home << Job #oncokb << Q13485.R361C
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q13485.R361C

Detailed results for job #oncokb produced by ELASPIC
Q13485, Mothers against decapentaplegic homolog 4:
R361C
1
552
MH1
MH2
Q53XR6, MAD, mothers against decapentaplegic homolog 2 (Drosophila):
1
467
MH1
MH2
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Model: Wild-type | Mutant | Both
Protein: Q13485 | Q53XR6 | Cofactors | All
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Q13485.R361C

Completed successfully

Protein, domain: Q13485 MH2

Interacting with: Q53XR6 MH2

PDB templates used: 1u7v_B, 1u7v_A

Seq identity: 0.881, 1.000 Model score: -0.513

ELASPIC ΔΔG: 1.148

ELASPIC2 (EL2) score: 2.153

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.