ELASPIC home << Job #oncokb << Q13233.E1286V
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q13233.E1286V

Detailed results for job #oncokb produced by ELASPIC
Q13233, Mitogen-activated protein kinase kinase kinase 1:
E1286V
1
1512
Pkinase
M4K4 isoform 4, Isoform 4 of Mitogen-activated protein kinase kinase kinase kinase 4:
1
1165
Pkinase
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Q13233.E1286V

Completed successfully

Protein, domain: Q13233 Pkinase

Interacting with: M4K4 isoform 4 Pkinase

PDB templates used: 3com_A, 3com_B

Seq identity: 0.302, 0.440 Model score: 0.346

ELASPIC ΔΔG: -0.050

ELASPIC2 (EL2) score: 0.487

Mutation run by user.

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Citation

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