ELASPIC home << Job #oncokb << Q13233.E1286V
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q13233.E1286V

Detailed results for job #oncokb produced by ELASPIC
Q13233, Mitogen-activated protein kinase kinase kinase 1:
E1286V
1
1512
Pkinase
HIPK2 isoform 3, Isoform 3 of Homeodomain-interacting protein kinase 2:
1
1171
Pkinase
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Q13233.E1286V

Completed successfully

Protein, domain: Q13233 Pkinase

Interacting with: HIPK2 isoform 3 Pkinase

PDB templates used: 4au8_B, 4au8_A

Seq identity: 0.283, 0.290 Model score: 0.946

ELASPIC ΔΔG: 0.366

ELASPIC2 (EL2) score: 0.012

Mutation run by user.

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Citation

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