ELASPIC home << Job #oncokb << Q06187.Y551F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q06187.Y551F

Detailed results for job #oncokb produced by ELASPIC
Q06187, Tyrosine-protein kinase BTK:
Y551F
1
659
PH+BTK
Pkinase_Tyr
SH3_1
SH2
TEC, Tyrosine-protein kinase Tec:
1
631
SH3_1
PH+BTK
SH2
Pkinase_Tyr
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Model: Wild-type | Mutant | Both
Protein: Q06187 | TEC | Cofactors | All
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Q06187.Y551F

Completed successfully

Protein, domain: Q06187 Pkinase_Tyr

Interacting with: TEC Pkinase_Tyr

PDB templates used: 3p08_A, 3p08_B

Seq identity: 0.951, 0.610 Model score: -0.935

ELASPIC ΔΔG: -0.098

ELASPIC2 (EL2) score: 1.071

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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