ELASPIC home << Job #oncokb << Q06187.Y551F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q06187.Y551F

Detailed results for job #oncokb produced by ELASPIC
Q06187, Tyrosine-protein kinase BTK:
Y551F
1
659
PH+BTK
Pkinase_Tyr
SH3_1
SH2
MET isoform 2, Isoform 2 of Hepatocyte growth factor receptor:
1
1408
Pkinase_Tyr
TIG
Sema+PSI
TIG
Select affected interaction:

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Q06187.Y551F

Completed successfully

Protein, domain: Q06187 Pkinase_Tyr

Interacting with: MET isoform 2 Pkinase_Tyr

PDB templates used: 3p08_B, 3p08_A

Seq identity: 0.977, 0.346 Model score: -0.347

ELASPIC ΔΔG: 3.202

ELASPIC2 (EL2) score: 1.286

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.