ELASPIC home << Job #oncokb << Q06187.Y551F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q06187.Y551F

Detailed results for job #oncokb produced by ELASPIC
Q06187, Tyrosine-protein kinase BTK:
Y551F
1
659
PH+BTK
Pkinase_Tyr
SH3_1
SH2
P85A isoform 4, Isoform 4 of Phosphatidylinositol 3-kinase regulatory subunit alpha:
1
732
SH2+SH2
RhoGAP
SH3_2
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Q06187.Y551F

Completed successfully

Protein, domain: Q06187 Pkinase_Tyr

Interacting with: P85A isoform 4 SH2+SH2

PDB templates used: 4gl9_A, 4gl9_E

Seq identity: 0.316, 0.304 Model score: -0.019

ELASPIC ΔΔG: 0.840

ELASPIC2 (EL2) score: 0.622

Mutation run by user.

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Citation

If you use these results, please cite the papers on this page.