ELASPIC home << Job #oncokb << Q06124.D61N
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q06124.D61N

Detailed results for job #oncokb produced by ELASPIC
Q06124, Tyrosine-protein phosphatase non-receptor type 11:
D61N
1
597
SH2
SH2
Y_phosphatase
HCK, Tyrosine-protein kinase HCK:
1
526
SH3_1
SH2
Pkinase_Tyr
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Model: Wild-type | Mutant | Both
Protein: Q06124 | HCK | Cofactors | All
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Q06124.D61N

Completed successfully

Protein, domain: Q06124 SH2

Interacting with: HCK SH2

PDB templates used: 1r1s_A, 1r1s_E

Seq identity: 0.442, 0.388 Model score: 0.082

ELASPIC ΔΔG: 0.999

ELASPIC2 (EL2) score: -0.051

Mutation in database: UniProt.

Download:  PDBwt   | PDBmut

Citation

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