ELASPIC home << Job #oncokb << Q04771.Q207E
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q04771.Q207E

Detailed results for job #oncokb produced by ELASPIC
Q04771, Activin receptor type-1:
Q207E
1
509
Activin_recp
TGF_beta_GS+Pkinase
ACVR1C, Activin receptor type-1C:
1
493
Activin_recp
TGF_beta_GS+Pkinase
Select affected interaction:

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Model: Wild-type | Mutant | Both
Protein: Q04771 | ACVR1C | Cofactors | All
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Q04771.Q207E

Completed successfully

Protein, domain: Q04771 TGF_beta_GS+Pkinase

Interacting with: ACVR1C TGF_beta_GS+Pkinase

PDB templates used: 3q4u_A, 3q4u_B

Seq identity: 0.997, 0.635 Model score: -0.738

ELASPIC ΔΔG: -0.325

ELASPIC2 (EL2) score: 1.018

Mutation in database: UniProt.

Download:  PDBwt   | PDBmut

Citation

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