ELASPIC home << Job #oncokb << Q02750.S222D
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q02750.S222D

Detailed results for job #oncokb produced by ELASPIC
Q02750, Dual specificity mitogen-activated protein kinase kinase 1:
S222D
1
393
Pkinase
CDK5 isoform 2, Isoform 2 of Cyclin-dependent kinase 5:
1
260
Pkinase
Pkinase
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Q02750.S222D

Completed successfully

Protein, domain: Q02750 Pkinase

Interacting with: CDK5 isoform 2 Pkinase

PDB templates used: 4au8_B, 4au8_A

Seq identity: 0.267, 0.974 Model score: 0.719

ELASPIC ΔΔG: 1.685

ELASPIC2 (EL2) score: 1.447

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.