ELASPIC home << Job #oncokb << Q02750.S218D
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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Q02750.S218D

Detailed results for job #oncokb produced by ELASPIC
Q02750, Dual specificity mitogen-activated protein kinase kinase 1:
S218D
1
393
Pkinase
VRK2 isoform 4, Isoform 4 of Serine/threonine-protein kinase VRK2:
1
390
Pkinase
Select affected interaction:

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Q02750.S218D

Completed successfully

Protein, domain: Q02750 Pkinase

Interacting with: VRK2 isoform 4 Pkinase

PDB templates used: 3op5_D, 3op5_C

Seq identity: 0.214, 0.582 Model score: 0.668

ELASPIC ΔΔG: 0.425

ELASPIC2 (EL2) score: 1.577

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.