ELASPIC home << Job #oncokb << Q02750.P306H
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q02750.P306H

Detailed results for job #oncokb produced by ELASPIC
Q02750, Dual specificity mitogen-activated protein kinase kinase 1:
P306H
1
393
Pkinase
EPHB1, Ephrin type-B receptor 1:
1
984
Ephrin_lbd
SAM_1
fn3
fn3
EphA2_TM+Pkinase_Tyr
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Protein: Q02750 | EPHB1 | Cofactors | All
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Q02750.P306H

Completed successfully

Protein, domain: Q02750 Pkinase

Interacting with: EPHB1 EphA2_TM+Pkinase_Tyr

PDB templates used: 2y4i_C, 2y4i_B

Seq identity: 0.897, 0.251 Model score: 0.585

ELASPIC ΔΔG: 0.974

ELASPIC2 (EL2) score: 0.880

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.