ELASPIC home << Job #oncokb << Q02750.E120Q
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

Q02750.E120Q

Detailed results for job #oncokb produced by ELASPIC
Q02750, Dual specificity mitogen-activated protein kinase kinase 1:
E120Q
1
393
Pkinase
MP2K4 isoform 2, Isoform 2 of Dual specificity mitogen-activated protein kinase kinase 4:
1
410
Pkinase
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Q02750.E120Q

Completed successfully

Protein, domain: Q02750 Pkinase

Interacting with: MP2K4 isoform 2 Pkinase

PDB templates used: 3aln_B, 3aln_A

Seq identity: 0.334, 0.879 Model score: 0.590

ELASPIC ΔΔG: -0.739

ELASPIC2 (EL2) score: 0.932

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.