ELASPIC home << Job #oncokb << P84022.R268A
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P84022.R268A

Detailed results for job #oncokb produced by ELASPIC
P84022, Mothers against decapentaplegic homolog 3:
R268A
1
425
MH1
MH2
SMAD2, Mothers against decapentaplegic homolog 2:
1
467
MH1
MH2
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Model: Wild-type | Mutant | Both
Protein: P84022 | SMAD2 | Cofactors | All
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P84022.R268A

Completed successfully

Protein, domain: P84022 MH2

Interacting with: SMAD2 MH2

PDB templates used: 1u7v_A, 1u7v_C

Seq identity: 0.970, 1.000 Model score: -1.066

ELASPIC ΔΔG: 1.710

ELASPIC2 (EL2) score: 3.252

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.