ELASPIC home << Job #oncokb << P84022.D408E
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P84022.D408E

Detailed results for job #oncokb produced by ELASPIC
P84022, Mothers against decapentaplegic homolog 3:
D408E
1
425
MH1
MH2
B7Z5N5, Mothers against decapentaplegic homolog 2:
1
431
MH1
MH2
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Model: Wild-type | Mutant | Both
Protein: P84022 | B7Z5N5 | Cofactors | All
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P84022.D408E

Completed successfully

Protein, domain: P84022 MH2

Interacting with: B7Z5N5 MH2

PDB templates used: 1u7f_C, 1u7f_A

Seq identity: 1.000, 0.963 Model score: -0.755

ELASPIC ΔΔG: 1.371

ELASPIC2 (EL2) score: 0.899

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.