ELASPIC home << Job #oncokb << P63000.G12V
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P63000.G12V

Detailed results for job #oncokb produced by ELASPIC
P63000, Ras-related C3 botulinum toxin substrate 1:
G12V
1
192
Ras
RHG32 isoform 3, Isoform 3 of Rho GTPase-activating protein 32:
1
322
RhoGAP
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P63000.G12V

Completed successfully

Protein, domain: P63000 Ras

Interacting with: RHG32 isoform 3 RhoGAP

PDB templates used: 2ngr_A, 2ngr_B

Seq identity: 0.703, 0.251 Model score: -0.899

ELASPIC ΔΔG: 1.835

ELASPIC2 (EL2) score: 2.443

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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