ELASPIC home << Job #oncokb << P63000.C157Y
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P63000.C157Y

Detailed results for job #oncokb produced by ELASPIC
P63000, Ras-related C3 botulinum toxin substrate 1:
C157Y
1
192
Ras
PAK4 isoform 2, Isoform 2 of Serine/threonine-protein kinase PAK 4:
1
426
PBD
Pkinase
Select affected interaction:

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P63000.C157Y

Completed successfully

Protein, domain: P63000 Ras

Interacting with: PAK4 isoform 2 Pkinase

PDB templates used: 2v55_D, 2v55_C

Seq identity: 0.458, 0.323 Model score: 0.327

ELASPIC ΔΔG: 2.169

ELASPIC2 (EL2) score: 2.349

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.