ELASPIC home << Job #oncokb << P62070.Q72L
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P62070.Q72L

Detailed results for job #oncokb produced by ELASPIC
P62070, Ras-related protein R-Ras2:
Q72L
1
204
Ras
RAPGEF1, Rap guanine nucleotide exchange factor 1:
1
1077
RasGEF_N+RasGEF
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Model: Wild-type | Mutant | Both
Protein: P62070 | RAPGEF1 | Cofactors | All
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P62070.Q72L

Completed successfully

Protein, domain: P62070 Ras

Interacting with: RAPGEF1 RasGEF_N+RasGEF

PDB templates used: 4nyi_Q, 4nyi_S

Seq identity: 0.605, 0.274 Model score: -0.118

ELASPIC ΔΔG: 0.843

ELASPIC2 (EL2) score: 2.755

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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