ELASPIC home << Job #oncokb << P62070.Q72L
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P62070.Q72L

Detailed results for job #oncokb produced by ELASPIC
P62070, Ras-related protein R-Ras2:
Q72L
1
204
Ras
RPGF1 isoform 3, Isoform 3 of Rap guanine nucleotide exchange factor 1:
1
1095
RasGEF_N+RasGEF
Select affected interaction:

Switch to the slower HTML5 mode if the applet isn't showing.
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P62070.Q72L

Completed successfully

Protein, domain: P62070 Ras

Interacting with: RPGF1 isoform 3 RasGEF_N+RasGEF

PDB templates used: 4nyi_Q, 4nyi_S

Seq identity: 0.605, 0.274 Model score: -0.069

ELASPIC ΔΔG: 0.947

ELASPIC2 (EL2) score: 2.462

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.