ELASPIC home << Job #oncokb << P61586.Y34F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P61586.Y34F

Detailed results for job #oncokb produced by ELASPIC
P61586, Transforming protein RhoA:
Y34F
1
193
Ras
ARHGEF25, Rho guanine nucleotide exchange factor 25:
1
580
RhoGEF
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Protein: P61586 | ARHGEF25 | Cofactors | All
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P61586.Y34F

Completed successfully

Protein, domain: P61586 Ras

Interacting with: ARHGEF25 RhoGEF

PDB templates used: 2rgn_C, 2rgn_B

Seq identity: 1.000, 1.000 Model score: -1.295

ELASPIC ΔΔG: 1.459

ELASPIC2 (EL2) score: 1.816

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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