ELASPIC home << Job #oncokb << P61586.R5Q
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P61586.R5Q

Detailed results for job #oncokb produced by ELASPIC
P61586, Transforming protein RhoA:
R5Q
1
193
Ras
ARHG2 isoform 2, Isoform 2 of Rho guanine nucleotide exchange factor 2:
1
985
RhoGEF
PH
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P61586.R5Q

Completed successfully

Protein, domain: P61586 Ras

Interacting with: ARHG2 isoform 2 RhoGEF

PDB templates used: 3qbv_C, 3qbv_D

Seq identity: 0.557, 0.281 Model score: -0.993

ELASPIC ΔΔG: 0.101

ELASPIC2 (EL2) score: 1.929

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.