ELASPIC home << Job #oncokb << P61586.E40W
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P61586.E40W

Detailed results for job #oncokb produced by ELASPIC
P61586, Transforming protein RhoA:
E40W
1
193
Ras
RGRF1 isoform 2, Isoform 2 of Ras-specific guanine nucleotide-releasing factor 1:
1
489
RasGEF
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P61586.E40W

Completed successfully

Protein, domain: P61586 Ras

Interacting with: RGRF1 isoform 2 RasGEF

PDB templates used: 1nvv_Q, 1nvv_S

Seq identity: 0.318, 0.293 Model score: 0.522

ELASPIC ΔΔG: 2.650

ELASPIC2 (EL2) score: 2.460

Mutation run by user.

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Citation

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