ELASPIC home << Job #oncokb << P61586.E40Q
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P61586.E40Q

Detailed results for job #oncokb produced by ELASPIC
P61586, Transforming protein RhoA:
E40Q
1
193
Ras
TRIO isoform 2, Isoform 2 of Triple functional domain protein:
1
2921
Spec..
..
Rh..
Pkinase
Select affected interaction:

Switch to the slower HTML5 mode if the applet isn't showing.
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P61586.E40Q

Completed successfully

Protein, domain: P61586 Ras

Interacting with: TRIO isoform 2 RhoGEF+RhoGEF

PDB templates used: 2rgn_C, 2rgn_B

Seq identity: 1.000, 0.390 Model score: -1.050

ELASPIC ΔΔG: -0.223

ELASPIC2 (EL2) score: 1.798

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.