ELASPIC home << Job #oncokb << P61586.E40N
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P61586.E40N

Detailed results for job #oncokb produced by ELASPIC
P61586, Transforming protein RhoA:
E40N
1
193
Ras
ARHGAP5, Rho GTPase-activating protein 5:
1
1502
FF
Ras
RhoGAP
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Model: Wild-type | Mutant | Both
Protein: P61586 | ARHGAP5 | Cofactors | All
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P61586.E40N

Completed successfully

Protein, domain: P61586 Ras

Interacting with: ARHGAP5 RhoGAP

PDB templates used: 1ow3_B, 1ow3_A

Seq identity: 0.994, 0.288 Model score: -1.260

ELASPIC ΔΔG: 0.685

ELASPIC2 (EL2) score: 1.890

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.