ELASPIC home << Job #oncokb << P52701.T1219I
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P52701.T1219I

Detailed results for job #oncokb produced by ELASPIC
P52701, DNA mismatch repair protein Msh6:
T1219I
1
1360
PWWP
MutS_I
MutS_II
MutS_III+MutS_V
MSH3, DNA mismatch repair protein Msh3:
1
1137
MutS_I
MutS_II
MutS_III+MutS_V
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Protein: P52701 | MSH3 | Cofactors | All
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P52701.T1219I

Completed successfully

Protein, domain: P52701 MutS_III+MutS_V

Interacting with: MSH3 MutS_III+MutS_V

PDB templates used: 2o8b_B, 2o8b_A

Seq identity: 0.887, 0.390 Model score: -0.099

ELASPIC ΔΔG: 1.225

ELASPIC2 (EL2) score: 2.267

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.