ELASPIC home << Job #oncokb << P52701.T1219I
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P52701.T1219I

Detailed results for job #oncokb produced by ELASPIC
P52701, DNA mismatch repair protein Msh6:
T1219I
1
1360
PWWP
MutS_I
MutS_II
MutS_III+MutS_V
E9PHA6, DNA mismatch repair protein Msh2:
1
921
MutS_I
MutS_II
MutS_III+MutS_V
Select affected interaction:

Switch to the slower HTML5 mode if the applet isn't showing.
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Protein: P52701 | E9PHA6 | Cofactors | All
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P52701.T1219I

Completed successfully

Protein, domain: P52701 MutS_III+MutS_V

Interacting with: E9PHA6 MutS_III+MutS_V

PDB templates used: 2o8b_B, 2o8b_A

Seq identity: 0.887, 0.962 Model score: -0.098

ELASPIC ΔΔG: -0.840

ELASPIC2 (EL2) score: 2.055

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.