ELASPIC home << Job #oncokb << P51587.R2659K
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P51587.R2659K

Detailed results for job #oncokb produced by ELASPIC
P51587, Breast cancer type 2 susceptibility protein:
R2659K
1
3418
BRCA-2_h..
B..
Q6IBB7, SHFM1 protein:
1
70
DSS1_SEM1
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Model: Wild-type | Mutant | Both
Protein: P51587 | Q6IBB7 | Cofactors | All
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P51587.R2659K

Completed successfully

Protein, domain: P51587 BRCA-2_helical+BRCA-2_OB1+Tower

Interacting with: Q6IBB7 DSS1_SEM1

PDB templates used: 1miu_A, 1miu_B

Seq identity: 0.800, 0.737 Model score: 0.203

ELASPIC ΔΔG: 1.207

ELASPIC2 (EL2) score: 0.468

Mutation in database: UniProt.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.