ELASPIC home << Job #oncokb << P51587.F1524V
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P51587.F1524V

Detailed results for job #oncokb produced by ELASPIC
P51587, Breast cancer type 2 susceptibility protein:
F1524V
1
3418
BRCA-2_h..
B..
RAD51 isoform 4, Isoform 4 of DNA repair protein RAD51 homolog 1:
1
340
HHH_5+Rad51
Select affected interaction:

Switch to the slower HTML5 mode if the applet isn't showing.
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P51587.F1524V

Completed successfully

Protein, domain: P51587 BRCA2

Interacting with: RAD51 isoform 4 HHH_5+Rad51

PDB templates used: 1n0w_B, 1n0w_A

Seq identity: 1.000, 0.858 Model score: 0.606

ELASPIC ΔΔG: 4.603

ELASPIC2 (EL2) score: 1.005

Mutation in database: UniProt.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.