ELASPIC home << Job #oncokb << P50148.Q209L
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P50148.Q209L

Detailed results for job #oncokb produced by ELASPIC
P50148, Guanine nucleotide-binding protein G(q) subunit alpha:
Q209L
1
359
G-alpha
GNB3, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3:
1
340
WD40
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Model: Wild-type | Mutant | Both
Protein: P50148 | GNB3 | Cofactors | All
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P50148.Q209L

Completed successfully

Protein, domain: P50148 G-alpha

Interacting with: GNB3 WD40

PDB templates used: 3ah8_A, 3ah8_B

Seq identity: 0.953, 0.836 Model score: -0.707

ELASPIC ΔΔG: -0.495

ELASPIC2 (EL2) score: 1.807

Mutation in databases: UniProt, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.