ELASPIC home << Job #oncokb << P50148.Q209L
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P50148.Q209L

Detailed results for job #oncokb produced by ELASPIC
P50148, Guanine nucleotide-binding protein G(q) subunit alpha:
Q209L
1
359
G-alpha
RGS2 isoform 3, Isoform 3 of Regulator of G-protein signaling 2:
1
196
RGS
Select affected interaction:

Switch to the slower HTML5 mode if the applet isn't showing.
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P50148.Q209L

Completed successfully

Protein, domain: P50148 G-alpha

Interacting with: RGS2 isoform 3 RGS

PDB templates used: 4ekd_A, 4ekd_B

Seq identity: 0.978, 0.985 Model score: -1.114

ELASPIC ΔΔG: 0.590

ELASPIC2 (EL2) score: 1.722

Mutation in databases: UniProt, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.