ELASPIC home << Job #oncokb << P45985.V321M
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P45985.V321M

Detailed results for job #oncokb produced by ELASPIC
P45985, Dual specificity mitogen-activated protein kinase kinase 4:
V321M
1
399
Pkinase
MAPK8, Mitogen-activated protein kinase 8:
1
427
Pkinase
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Protein: P45985 | MAPK8 | Cofactors | All
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P45985.V321M

Completed successfully

Protein, domain: P45985 Pkinase

Interacting with: MAPK8 Pkinase

PDB templates used: 2g01_A, 2g01_B

Seq identity: 0.243, 0.994 Model score: 0.433

ELASPIC ΔΔG: 1.158

ELASPIC2 (EL2) score: 0.977

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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