ELASPIC home << Job #oncokb << P45985.N234I
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P45985.N234I

Detailed results for job #oncokb produced by ELASPIC
P45985, Dual specificity mitogen-activated protein kinase kinase 4:
N234I
1
399
Pkinase
MP2K6 isoform 2, Isoform 2 of Dual specificity mitogen-activated protein kinase kinase 6:
1
278
Pkinase
Select affected interaction:

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P45985.N234I

Completed successfully

Protein, domain: P45985 Pkinase

Interacting with: MP2K6 isoform 2 Pkinase

PDB templates used: 3enm_A, 3enm_C

Seq identity: 0.557, 0.953 Model score: -0.733

ELASPIC ΔΔG: 1.465

ELASPIC2 (EL2) score: 1.646

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.