ELASPIC home << Job #oncokb << P45985.A279T
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P45985.A279T

Detailed results for job #oncokb produced by ELASPIC
P45985, Dual specificity mitogen-activated protein kinase kinase 4:
A279T
1
399
Pkinase
MK08 isoform 3, Isoform 3 of Mitogen-activated protein kinase 8:
1
384
Pkinase
Select affected interaction:

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P45985.A279T

Completed successfully

Protein, domain: P45985 Pkinase

Interacting with: MK08 isoform 3 Pkinase

PDB templates used: 2g01_A, 2g01_B

Seq identity: 0.243, 0.969 Model score: 0.396

ELASPIC ΔΔG: -0.583

ELASPIC2 (EL2) score: -0.606

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.