ELASPIC home << Job #oncokb << P45985.A279T
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P45985.A279T

Detailed results for job #oncokb produced by ELASPIC
P45985, Dual specificity mitogen-activated protein kinase kinase 4:
A279T
1
399
Pkinase
FLT4, Vascular endothelial growth factor receptor 3:
1
1363
I-set
Ig_2
Ig_2
Ig_2
I-set
Pkinase_Tyr
Select affected interaction:

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Model: Wild-type | Mutant | Both
Protein: P45985 | FLT4 | Cofactors | All
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P45985.A279T

Completed successfully

Protein, domain: P45985 Pkinase

Interacting with: FLT4 Pkinase_Tyr

PDB templates used: 4j96_B, 4j96_A

Seq identity: 0.247, 0.466 Model score: 0.648

ELASPIC ΔΔG: -0.640

ELASPIC2 (EL2) score: 0.076

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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