ELASPIC home << Job #oncokb << P45985.A279T
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P45985.A279T

Detailed results for job #oncokb produced by ELASPIC
P45985, Dual specificity mitogen-activated protein kinase kinase 4:
A279T
1
399
Pkinase
ROCK2, Rho-associated protein kinase 2:
1
1388
R..
PH
Pkinase
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Protein: P45985 | ROCK2 | Cofactors | All
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P45985.A279T

Completed successfully

Protein, domain: P45985 Pkinase

Interacting with: ROCK2 Pkinase

PDB templates used: 2f2u_B, 2f2u_A

Seq identity: 0.270, 0.972 Model score: -0.119

ELASPIC ΔΔG: 0.168

ELASPIC2 (EL2) score: -1.241

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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