ELASPIC home << Job #oncokb << P42771.R87W
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P42771.R87W

Detailed results for job #oncokb produced by ELASPIC
P42771, Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3:
R87W
1
156
Ank
TUBB4B, Tubulin beta-4B chain:
1
445
Tubulin+Tubulin_C
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Model: Wild-type | Mutant | Both
Protein: P42771 | TUBB4B | Cofactors | All
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P42771.R87W

Completed successfully

Protein, domain: P42771 Ank

Interacting with: TUBB4B Tubulin+Tubulin_C

PDB templates used: 4drx_E, 4drx_D

Seq identity: 0.371, 0.976 Model score: -0.748

ELASPIC ΔΔG: 1.453

ELASPIC2 (EL2) score: 0.345

Mutation in databases: UniProt, COSMIC, COSMIC, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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